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Tranilast: a potential anti-Inflammatory and NLRP3 inflammasome inhibitor drug for COVID-19

Viral titers plateaued during the first 3 days post-infection (6.9 9.9 10 2 , 6.0 7.5 10 2 , 6.0 6.6 10 2 nsp14 copies/ng of RNA on D1, D2, and D3, respectively) and then progressively decayed close to the limit of detection by D6

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Mechanistically, E4s primary effect was to alleviate inflammatory responses and vascular abnormalities, with relatively modest inhibitory effects on VEGF [62]

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