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[12] Sermorelin and Potential Synergism with Other Peptides Sermorelin is a GHRH analog which may exert potential synergism when combined with ghrelin mimetics

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In human growth-hormone-deficiency trials using recombinant native IGF-1 (mecasermin, brand name Increlex), the approved dose range is 0.04-0.12 mg/kg twice daily by subcutaneous injection, titrated to IGF-1 levels in the age- and sex-normalised reference range [15]

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Multiple other causes should be considered including peripheral vascular disease, neuropathy, medication effects from other drugs (particularly diuretics, beta-agonists, and statins), hypothyroidism, pregnancy, and musculoskeletal conditions

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