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oral is viable for GI endpoints and (with dose adjustment) systemic endpoints

Pharmacol Res 159:104928

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(2025) used yeast cell wall microparticles to coencapsulate Bacillus subtilis and rheinan anthraquinone from rhubarb with anti-inflammatory activity (2025) designed an 18-glycyrrhetinic acid prodrug nanomicelle that, when combined with Lactobacillus rhamnosus GG, repaired the intestinal barrier and inhibited microglia-mediated neuroinflammation, thereby alleviating UC and concomitant depressive-like behaviors

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