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The expression of the immunoproteasome 5i, which is important for the degradation of oxidized proteins under stressful conditions, was decreased in ibuprofen treated male livers relative to controls whereas it was increased in female mice livers in ibuprofen treated group

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GHK-Cu also restores antioxidant defenses by upregulating Nrf2 expression, which is crucial for combating oxidative damage in COPD 7