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Luciferase activity was quantified using a dual-luciferase assay system (Promega, E1910)

Interestingly, elevated G6PD is not observed in liver cirrhosis which is a main cause of liver cancer, indicating that G6PD might play an important role in promoting malignant transformation (88)

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Nat Med 10(8):858864 Wolf MJ et al (2012) Endothelial CCR208 signaling induced by colon carcinoma cells enables extravasation via the JAK2-Stat5 and p38MAPK pathway

In contrast, the Lys8 residue had a different conformation in the oxidized state of Cys20 as shown in our oxidized OsDHAR structure