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In 2022, SAR441255 (GLP-1/GIP/glucagon receptor triagonist) was administered to obese, diabetic primates and healthy lean to overweight humans without diabetes

Benefits: Increase exercise capacity of muscles

A thoughtful research program may employ all three and this peptide is often the entry point because its effects are the most rapidly measurable and the most visually apparent

Because much of the clinical trial data is limited to patients with diabetes, obesity, or both, it is possible that the disease-modifying effects of GLP1RA are due to the mitigation of metabolic abnormalities associated with these conditions

Yu V, Ballou S, Hassan R, Singh P, Shah E, Rangan V, et al

The move comes after the FDA took tirzepatide, the key ingredient in Eli Lilly's (LLY) diabetes drug Mounjaro and weight-loss drug Zepbound, off its shortage list