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However, issues included the use of toxic cyanide-containing substances, the high cost of resolving agents and catalysts, the challenge of utilizing the other enantiomer from the resolution, numerous reaction steps, low yield, high cost, and high product price

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In a transected Achilles tendon model in rats, the Sikiric group reported dose-dependent improvement in functional recovery, biomechanical strength, and histological healing markers compared with saline-treated controls [Sikiric et al., Inflammopharmacology, 2018]