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Statements Author contributions AS: literature survey, preparation of figure, manuscript writing, and editing

Understanding the interaction between the gut microbiome and the glymphatic system presents a new pathway for regulating memory and cognitive health, which could be an important target for the prevention and treatment of neurodegenerative diseases

JAM-A orchestrates the spatiotemporal association of scaffold molecules such as ZO-2 and Afadin that associate with Rap activators such as PDZ-GEFs to modulate activity of small GTPases in the Rap and Rho family, in order to regulate barrier function and integrin-dependent cell migration both in vitro and in vivo (Monteiro et al., 2013)

G, Detail (x200) of the nail matrix

Allocation was determined by investigator not involved in the assessment or intervention

(Silver fillings slowly release mercury into the body.) Eating a poor-quality diet (for example, eating farm-raised fish that carry high levels of mercury)