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doi: 10.1073/pnas.1201994109 22 ButlerAAKestesonRAKhongKCullenMJPelleymounterMADekoningJet al

Based on the analysis of the literature on the mitochondrial Ca 2+ regulation in cyclophilin D (SypD)-deficient mice and neurons, Rizzuto et al

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First, S100A8/S100A9 promotes tumor cell growth through the activation of the NF-B signaling pathway in a RAGE-dependent manner (126), while S100A8/S100A9 can interact with RAGE (127)

This process involves enzymes like NADPH oxidase and myeloperoxidase, which produce superoxide and hypochlorous acid (HOCl), respectively

Schafer SA, Mussig K, Staiger H, Machicao F, Stefan N, Gallwitz B, et al