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In non-clinical research literature, the GHK-Cu peptide is discussed as a signaling molecule that works at the cellular level, including effects on human genes tied to tissue repair, collagen synthesis, collagen and elastin remodeling, glycosaminoglycan expression, and overall skin quality within controlled laboratory systems

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328 ADI-PEG-20, in combination with pemetrexed and cisplatin (ADIPEMCIS), was well tolerated in another phase I study of recurrent high-grade glioma (HGG) (NCT02029690)