Proteins such as tau, TDP-43, -synuclein, and polyglutamine-expanded proteins misfold and aggregate into toxic species that overwhelm the UPS and interfere with normal degradation processes
Benzyl Alcohol Considerations While benzyl alcohol is an FDA-approved preservative for multi-dose vial formulations, it is important to note that: Benzyl alcohol has been associated with adverse effects in neonates (very young infants) at high concentrations when used as a preservative in injectable products Use in pediatric or neonatal populations should follow institutional guidelines and medical supervision Practitioners should be aware of any patient-specific contraindications or sensitivities Product use should always align with the prescribing information and clinical judgment of licensed healthcare providers Storage and Handling Requirements Temperature: Store at controlled room temperature (typically 6877F / 2025C)
& Hermes-Lima, M
40 :1260-5 Stphane Chevaliez , PharmD, PhD, is Assistant Professor at the University of Paris XII and a member of the Department of Virology and of INSERM Unit U635 at the Henri Mondor University Hospital in Crteil, France
Mol.Genet.Metab 2010;100(1):46-50
Yes, we supply our BPC-157 10 mg (10 Vials) exclusively for laboratory research purposes