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the difference between AOD-9604 arms and placebo was not statistically significant at either point, and development was terminated
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NNMT slows down fat cell metabolism (which makes losing weight even more difficult.) By blocking NNMT, 5 Amino 1MQ can prevent this metabolism slow-down and promote weight loss
Cartilage and joint research context A separate animal line of work has investigated AOD-9604 in joint research
A 12-week randomized trial demonstrated: Average weight loss of 2.6 kg in AOD-9604 group (1 mg/day) versus 0.8 kg in placebo group Preferential reduction in abdominal and visceral fat deposits No adverse effects on carbohydrate metabolism or insulin sensitivity Non-dose-dependent effects, with higher doses (10 mg/day) producing less weight loss than lower doses However, a subsequent 24-week Phase III trial with 502 subjects incorporating intensive diet and exercise showed no statistically significant weight loss compared to placebo, leading to development termination in 2007