Once absorbed, B12 binds to transport proteins called transcobalamins, which carry it to tissues throughout the body
A common pattern involves using higher doses (2mg daily) during the first cycle, then transitioning to maintenance doses (1mg 2-3x weekly) for subsequent cycles
K.BehlT.et al (2022)
MethodAmount
Key Benefits: Supports antioxidant defenses and cellular protection Promotes healthy mitochondrial and detoxification function Delivers stable, absorbable S-Acetyl-L-Glutathione (Emothion) Convenient lozenge form with clean ingredients How It Works: Emothion S-Acetyl-L-Glutathione is a stabilized form of glutathione that resists degradation in the digestive tract, promoting antioxidant activity and cellular detox
Common Causes and Contributors: From Vascular to Medication Effects When I assess ED, I use a structured framework: Vascular (vasculogenic) Atherosclerosis, endothelial dysfunction, impaired NO signaling Diabetes-related microvascular disease Hypertension-related vascular remodeling Neurogenic Peripheral neuropathy (diabetes, B12 deficiency, chemotherapy) Post-surgical or post-radiation nerve injury (e.g., radical prostatectomy) Spinal stenosis, discopathy, or pelvic nerve entrapment Hormonal Low testosterone (hypogonadism): impacts libido and PDE5 responsiveness Thyroid dysfunction, hyperprolactinemia, cortisol dysregulation Aromatization and unfavorable T:E2 ratios Psychogenic Depression, anxiety, relationship stress, sexual trauma history Performance anxiety and maladaptive autonomic patterns Drug-induced Antihypertensives (e.g., beta blockers, thiazides) SSRIs/SNRIs, antipsychotics Opioids and androgen suppression Iatrogenic and trauma-related Pelvic surgeries, radiation fibrosis Pelvic fractures, lumbar/pelvic injuries Lifestyle and sleep Sedentary behavior, obesity, poor diet, alcohol use Sleep apnea (major factor in testosterone and endothelial dysfunction) Biomechanics and pain Pelvic floor hypertonicity or dyssynergia SI joint dysfunction, lumbar facet syndromes, hip pathology This framework helps us prioritize diagnostics and personalize treatment
