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GSH/GSSH ratio for DMSO control and compounds were calculated using (Net DMSO total glutathione RFU) (Net DMSO GSSG RFU)/ (Net DMSO GSSG RFU)/2 and (Net inhibitor total glutathione RFU) (Net inhibitor GSSG RFU)/ (Net inhibitor GSSG RFU)/2 respectively

Many biochemical reactions in the human body are enzyme catalyzed reactions, most of these enzymes with thiol as active groups, the state of the thiol group determines the activation and inhibition of enzyme activity

In urothelial cells from the bladder of individuals with ulcerative IC, amplified expression of TNF- has been observed

The authors mention that the combination of two different ligands around palladium(II) enhances the cytotoxicity of metallodrugs