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Without sufficient NAD+, these enzymes cannot functionwhich explains why the decline in NAD+ with age leads to a cascade of cellular dysfunctions (Katsyuba et al., Nat Metab 2020)

doi: 10.1038/ejcn.2014.46

In particular, Epithalon has been shown to affect neuronal stem cell differentiation by promoting the growth and development of neurons from stem cell progenitors[2]

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Additionally, other types of NAMPT activators, such as NAT-5r and SBI-797812, have demonstrated effectiveness in a mouse model for CIPN, which may indicate their therapeutic promise in cognitive disorders 224 (Fig