In the STEP clinical trials, patients weighing over 100 kg (220 lbs) tended to need the full 2.4 mg maintenance dose for optimal results, while those under 80 kg (176 lbs) sometimes achieved their goals at 1.0 or 1.7 mg
Tirzepatide dose steps and why side effects change at each increase Both Mounjaro and Zepbound follow the same six-step schedule: 2.5 mg weekly for four weeks (tolerability only), then 5 mg, 7.5 mg, 10 mg, 12.5 mg, and 15 mg at minimum four-week intervals
But heres what the studies dont tell you success isnt just about the number on the scale
Experiencing these effects does not necessarily mean that treatment is unsuitable
Plateaus often resolve naturally within 24 weeks as your metabolism adjusts, but some patients benefit from small dose increases or behavioral resets
If you have Hashimotos, you should pay close attention to your selenium intake and use supplements if necessary to boost your levels