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Physiological actions of GLP-1 RAs as semaglutide have been discussed in Figure 2 [85] Semaglutide, a glucagon-like peptide- 1 receptor agonist, has been shown to reduce the risk of adverse cardiovascular events in patients with diabetes [86,87] as observed in hypothesis by Lincoff AM et al.29 Weight Reduction by 3%, 5%, 10%, 15%, and 20% is enough to achieve a significant improvement in cardiovascular events [88,89].Treatment options to manage post-surgery excess weight regain are scarce [90,91]

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