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Increases capillary density in muscle tissue to improve blood flow and nutrient delivery during repair

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The secondary outcomes were insulin, HOMA-IR, HbA1c, GLP-1, Glucagon, total cholesterol, triglycerides, HDL-C, low-density lipoprotein-cholesterol (LDL-C), ALP, AST, ALT, GT, TNF- , IL-6, hsCRP, antioxidant capacity and serum lipid peroxidation, body weight, body mass index (BMI), muscle mass, fat mass, and systolic and diastolic blood pressure Statistical analysis Sample size was established using the SigmaStat32 software, with significance level of 5% and 80% power

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Relative gene expression was calculated after normalization to a house-keeping gene (mouse or human 18S rRNA)