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Topiramate attenuates dural vasodilation primarily by inhibiting nitric oxide-mediated release of CGRP from preganglionic fibers of the trigeminal nerve (Akerman and Goadsby, 2005)

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Vitamin D acts as a transcriptional regulator for eNOS, leading to enhanced production of NO, which is known as the most powerful vasodilator in the vasculature [141]

After a lackluster first half of 2025, healthcare stocks staged a comeback, posting the best performance among the 11 S&P 500 sectors over the past six months