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Enhanced satiety signals (better control over cravings)

All GLP-1 medications must be prescribed by a doctor

Quercetin suppresses apoptosis of chondrocytes induced by IL-1 via inactivation of p38 MAPK signaling pathway

This triple mechanism of action distinguishes retatrutide from existing approved therapies such as semaglutide (a GLP-1 receptor agonist) or tirzepatide (a dual GIP/GLP-1 receptor agonist)

10.1016/j.molmet.2022.101449 2 AronneL

Individuals who screen positive or have a history of eating disorders should be referred to an obesity medicine specialist and an eating disorders specialist prior to prescribing GLP-1s