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For skin-brightening effects, noticeable changes often occur after 6 to 12 sessions administered over several weeks
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Paiva GS, Taft CA, Carvalho MC, de Souza IA, da Silva EC, Cavalcanti KP, et al A comparative study of the effects of Vitamins C and E in the development of sarcoma 180 in mice J Cancer
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These effects led to a decrease in colonic inflammation in ulcerative colitis models