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Its longer half-life (approximately 2 hours vs
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Ensuring adequate nutrition despite reduced appetite is crucial
Among the patients who develop NASH, 1020% will progress to higher-grade fibrosis and approximately 5% will develop overt cirrhosis (1) ( Figure 1 Triglycerides (TG) accumulation is likely one of the first steps in the pathophysiology of NAFLD as a result of an impaired free fatty acid (FFA) metabolism in the liver (Figure 2)
Mortality gains from these drugs could change how we view metabolic risks in underwriting and unlock new opportunities to design and offer products centered around different metabolic risk profiles
Some patients benefit from dose reduction followed by slower re-escalation, while others find symptom relief by switching between semaglutide and tirzepatide formulations or adjusting injection frequency
