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2 We dont yet have long-term trials on the newest GLP medications like tirzepatide, which targets two metabolic pathways instead of one but early data suggest potentially even bigger reductions in both serious cardiac events and overall mortality

Marked insulinotropic effects have been observed in T2DM patients with a single injection of liraglutide (120) or acute infusion of exenatide (121)

[1] [2] They work by mimicking the action of naturally occurring GLP-1, an incretin hormone released by the intestine in response to food intake

For diabetes management, treatment duration depends on ongoing glycaemic control and tolerability