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Balshaw T, et al

By Daria Esterhzy Daria Esterhzy is in the Department of Pathology, University of Chicago, Chicago, Illinois 60637, USA

Gene therapy involves permanently modifying cellular DNA

Significant anti-inflammatory effects were shown by a high dose of semaglutide, which caused the microglia polarization shifting to M2 as shown by lessening the concentrations of TNF- and i-NOS to 38.29 and 43.48%, respectively, in contrast to elevating arginase-1 and IL-4 to 1.89- and 2.55- folds, respectively, in comparison with reserpine group (Fig