Numerous enzymes involved in folate transport and metabolism are encoded by genes located on chromosome 21 and represent a potential mechanistic basis for folate dysregulation in children with DS
Arjmand B, Rabbani Z, Soveyzi F, Tayanloo-Beik A, Rezaei-Tavirani M, Biglar M, Adibi H, Larijani B (2023) Advancement of organoid technology in regenerative medicine
Further research should focus on optimizing delivery, assessing safety and efficacy, and exploring targets within iron transport and metabolism pathways
doi: 10.1111/jcmm.17402
44 An open-label, uncontrolled trial in 51 patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) found improvements in 34 patients after 3 months of supplementation with hydroxo-B12, 10 000 mcg twice per week as nasal drops
J Exp Med 207(3):505520 Dieterich LC et al (2012) Transcriptional profiling of human glioblastoma vessels indicates a key role of VEGF-A and TGFbeta2 in vascular abnormalization