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(2016) conducted a targeted metabolomic analysis to investigate metabolic abnormalities in male participants, including 20 healthy controls (HC), 20 individuals with GWS (diagnosed using both Kansas and CDC criteria), and 22 ME/CFS patients from a previous cohort diagnosed with 2015 Institute of Medicine, CCC, and CDC-1994 diagnostic criteria

Dysregulation of Sirts, particularly Sirt1, Sirt2 and Sirt3, has been linked to mitochondrial dysfunction, oxidative stress, and neurodegeneration in PD

(68) highlighted in their review that pH-sensitive nanoparticles- commonly composed of materials such as alginate and chitosan- can modulate their size, solubility, and drug release rate in response to pH-dependent physicochemical changes

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Current Neuropharmacology, 14 (8), 857