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doi: 10.3390/ijms19051478 66 VialGDetailleDGuigasB

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In about 17,600 adults with obesity and established cardiovascular disease but no diabetes, semaglutide cut major cardiovascular events by 20% over roughly 40 months. This is a secondary-prevention result in people who already had heart disease

Highly expressed EGFR contributes towards regional lymph node metastasis and poor outcomes

Endothelial-to-mesenchymal transition is induced by high glucose, TGF- signaling, and inflammatory cytokines, and is implicated in fibrosis and plaque instability (33, 34)

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