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Because NAD+ is used in hundreds of enzymatic reactions throughout the body, particularly in tissues with high energy demands, replenishing NAD+ levels directly via injection may support a more robust and sustainable cellular response

2 Mitochondrial dysfunction and energy metabolism abnormalities Mitochondrial dysfunction and the subsequent abnormalities in energy metabolism are thought to be one of the core potential mechanisms underlying PEM

[DOI] [PMC free article] [PubMed] [Google Scholar] 75.Adams LA, Anstee QM, Tilg H, Targher G