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However, side effects can occur, particularly with inappropriate dosing

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(3) It minimizes sustained membrane depolarization, raises the threshold for migraines, inhibits the release of CGRP and glutamate from the trigeminal vascular nerve endings, blocks high-voltage activated Ca 2+ channels, and reduces or prevents the release of neurotransmitters and vasoactive peptides (Dodick, 2018)

These metabolites, by activating G protein-coupled receptors (GPR41/43) on intestinal epithelial cells, further enhance barrier integrity and suppress the NF-kB signaling pathway, thereby mitigating systemic inflammation (Siddiqui and Cresci, 2021)

(126) observed that GLP-1R signaling exerted more robust control of -cell survival, relative to GIPR activation