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After coincubating freshly isolated and activated mouse T cells with particles encapsulated with EGFP or luciferase mRNA for 24 h, the CD5/ LNP group exhibited significantly higher EGFP or luciferase expression rates than did the unmodified LNP group (Fig

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This finding suggests possible non-monotonic dose-response (NMDR) effects, where low-dose exposure may produce different biological responses compared to higher exposure levels (79)

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