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But studies in mice and rabbits suggest that the drugs may raise the risk of birth defects and pregnancy loss and restrict fetal growth

Currently, taking glucose sensitizing agents, including metformin, SGLT-2 inhibitor, and GLP-1 agonist, is an effective way of lowering insulin levels and controlling PDA development at the same time

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First, because tesamorelin raises IGF-1, its label carries GH-class cautions contraindications in active malignancy and pregnancy, and glucose monitoring even though the trials did not show significant glycemic worsening