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Interestingly, the transcription factor c-Myc (involved in tumorigenesis in several cancers) can both promote proline (and also serine [101]) synthesis and inhibit proline breakdown [102], contributing to the protumor effects of proline

(3) FDA-approved indications include postoperative or postpartum nonobstructive urinary retention and neurogenic bladder atony

This combination strategy not only inhibits tumor growth but also antagonizes adaptive and metastatic behaviors driven by mutant p53

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However, it has been demonstrated that this variant is not associated with venous thrombosis risk in the heterozygous state

Molecular mechanisms of superoxide production by the mitochondrial respiratory chain