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Adipose tissue converts circulating T into estradiol (E2) since it expresses the aromatase enzyme

References Double-blinded comparison of diphenhydramine versus lidocaine as a local anesthetic The objective of this study was to evaluate the efficacy, onset of action, duration of action, and side effects of 1% diphenhydramine compared with 1% lidocaine when used as a local anesthetic agent

Specifically, cell viability plummeted to 31% 0.78% following an 8-hour hypoxic exposure