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however, OCTN2 does not exhibit the distal disulfide seen in OCTs (C60-C121 in OCT1)

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There have been studies where people have been injected with an amount of LPS that is similar to what you would find your gut releasing into your bloodstream, or a placebo control, which in this case was saline

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Newer oral GLP-1 options like the Wegovy pill are more affordable currently around $149 per month but clinical trials show they deliver somewhat less weight loss than injectables, averaging around 1516% compared to 20% or more with injections. For patients who need significant weight loss to resolve health conditions, a lower-cost medication that produces fewer results may not be enough