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Higher risk factors were a history of type 2 diabetes, tobacco use and advanced chronic kidney disease ( stage 3)

MHb, Methemoglobin

Titration support Follow-up visits help manage dose adjustments and gastrointestinal side effects over time

This finding is at risk of increased type I error because the analyses were not adjusted for multiple comparisons

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The evidence base is almost entirely preclinical: rodent models consistently show accelerated tissue repair, gut healing, and neurological protection, but human RCT data remains largely absent