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This dual action can lead to more significant reductions in blood sugar and body weight compared to medications that target only one hormone

Recent studies have suggested that I h currents can exert inhibitory effects by increasing the rheobase (minimum current required for firing), thereby reducing firing probability in small-diameter DRG neurons (Liu et al., 2022

Liu J, Huang X, Zhang F, Luo X, Yu W, Li C et al (2023) Metal-free multifunctional nanozymes mimicking endogenous antioxidant system for acute kidney injury alleviation

Control, p .05, Table 1)

DNA damaging effects, oxidative stress responses and cholinesterase activity in blood and brain of Wistar rats exposed to 9-tetrahydrocannabinol

Thus, we sought to identify a small-molecule GLP-1R agonist that is orally bioavailable using standard formulations, and has the potential to be combined with other oral small molecule therapeutics