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These changes are generally indirect rather than a direct pharmacological effect of semaglutide or tirzepatide on reproductive hormones
FDA.gov (accessed 2 September 2025)
At week 40, the difference between the top and bottom quartiles was an additional 8.3 lbs of weight lossabout 25% more weight lossfor the most highly-engaged group
If heart rate is bothersome: Reduce caffeine (compounds effect)
What electrolytes help with on GLP-1 Electrolytes help support: Hydration Energy Muscle function Exercise tolerance Nerve signaling Recovery They can also help if low intake is contributing to symptoms like fatigue or dizziness
doi: 10.3233/JAD-2010-1314 152 PerryTLahiriDKSambamurtiKChenDMattsonMPEganJMet al
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