It doesnt exclude a whole lot of patients, remembering that the prevalence of medullary thyroid cancer and MEN 2 in the general adult population is somewhere between 1 in 30,000 and 1 in 40,000. Pearce adds that patients and doctors alike should not be unduly concerned by any possible effects on the thyroid
The public embraced it before science caught up
Owing to its rare occurrence, even the most renowned clinical cancer centers do not have a large enough cohort of oral melanoma cases to reliably and significantly correlate the histologic findings with prognosis
Of particular interest to the GDP is actinic cheilitis (AC) - AK of the lip - which is associated with the same risk factors but a higher risk of malignant progression
J Pharmacol Exp Ther 263 (1): 170-9 (1992)
Patients with a history of pancreatitis, medullary thyroid cancer, or multiple endocrine neoplasia type 2 should never take GLP-1 medications, regardless of inflammatory bowel disease status