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Nat Rev Mater 2022;7:31431

Regarding the handling of possible medication use beyond the limited scope of the drug specification, clinicians are required to fill out and submit the Application form for filing of off-label drug use developed with the assistance of the information pharmacist, as well as the corresponding evidence-based medical evidence [36, 37], which can only be implemented after consideration and approval by the hospital

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But their broad adoption raises questions about access, cost, off-label use, and long-term safety