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[8] Overall, these side effects are short-lived and manageable, often improving by slowing the rate of administration or taking breaks during an intravenous infusion if needed

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However, a number of studies have indicated that peroxisomal -oxidation has a significantly lower capacity than that of mitochondrial -oxidation, particularly in muscle ( Reference Henderson and Tocher 63 Reference Fryland, Lie and Berge 65 )