doi: 10.1038/ncomms3905
Increased pigmentation also occurs when there is proliferation in the number of normally melanized keratinocytes (epithelial hyperplasia) and/or when there is an increased retention of normally melanized keratinocytes in the stratum corneum
Indeed, mice with defects of NOX2 or NOS2 failed to restrain bacterial replication (23, 24)
Lipids potently increase CCK release 180,181 , and administration of CCK-1R antagonists blocks the satiating effects of intestinal lipid infusion in both rodents and humans 169,182
Clinical trials may involve different patient populations, doses, treatment lengths, diabetes status, lifestyle support, and study designs
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