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Meister, Regulation of gamma-glutamyl-cysteine synthetase by nonallosteric feedback inhibition by glutathione

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Conclusions The results of this study indicate that low-dose (0.025 mg/kg) oral rapamycin, administered three times a week for one to five months to healthy, middle-aged large breed dogs, resulted in detectable concentrations of rapamycin in four dogs that was measurable in ng/ml