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Human PCSK5 genetic variants may influence high-density lipoprotein (HDL) levels, possibly through the inactivation of endothelial lipase 16,20

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A2A receptor activation upregulates vascular endothelial growth factor (VEGF), promotes angiogenesis in the dermal microvasculature, stimulates fibroblast migration and proliferation, and suppresses inflammatory cytokine release

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