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The dose is then increased to 0.5 mg weekly, with further increases to 1 mg or 2 mg weekly possible after at least 4 weeks at each step, depending on individual response and tolerability

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These findings reveal that although probiotics could have some positive impact on bone metabolism in certain specific situations, their effectiveness may vary depending on individual variations, study design, intervention period, and other variables

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The global surge in type 2 diabetes, which is largely driven by sedentary behavior, nutritional transitions, and rapid urbanization, has paralleled the rising incidence of DKD, as underscored by recent reports from the International Diabetes Federation (IDF) and the World Health Organization (WHO) (Figure 2) (Pereira et al., 2022