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In clinical trials for tirzepatide , people taking the highest dose lost up to 22.5% of their body weight after 72 weeks

5 - PMID 37786396 - Tirzepatide vs Insulin Lispro Added to Basal Insulin in Type 2 Diabetes: The SURPASS-6 Randomized Clinical Trial, JAMA (2023)

[1] This multi-faceted approach results in substantial weight reductionclinical trials in the STEP programme have demonstrated average weight loss of approximately 15% of initial body weight over 68 weeks when combined with lifestyle interventions, though individual results may vary

For those diagnosed with a true deficiency , injections might be needed weekly or monthly until levels are normalised, GP surgeries would typically schedule B12 injectsions every 12 weeks thereafter

The microbiota-gut-brain axis Physiological Reviews 2019;99(4):1877-2013

For comparison, Semaglutides nausea rate sits at 44%, making Retatrutides profile meaningfully more tolerable despite its greater potency