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However, under OA conditions, these MSCs are reprogrammed toward pro-inflammatory phenotypes, losing their reparative capacity and instead contributing to disease propagation

For example, ~54% (6 of 11) CRPC patients with MMR mutations or MSI-high tumors achieved a 50% reduction in PSA level after treatment with pembrolizumab

Hohaus C, Ganey TM, Minkus Y, Meisel HJ: Cell transplantation in lumbar spine disc degeneration disease