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Those enzymes do much of the "heavy lifting" for GSH

While renal function is the primary safety determinant, genetic variants in GLP-1 receptor and related metabolic pathways may help provide context on how your body responds to GLP-1 therapy, which can be interpreted with your healthcare provider to refine treatment selection

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We don't fully understand the weight loss-independent mechanisms through which GLP-1 reduces inflammation is it through the brain, or via T cells, or other pathways

References Abdolrasulnia R, Wood JL (1980) Persulfide properties of thiocystine and related trisulfides

This effect is particularly valuable during caloric deficits when fat oxidation is the primary energy source