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doi:10.3389/fnut.2014.00014 Lffek S, Schilling O, Franzke CW (2011) Biological role of matrix metalloproteinases: a critical balance

So that's kind of a good first step just to be on the on the alert and always start low taper up don't ever go over the top on it always start low work your way up try to make sure you're working with a practitioner so you have ways to monitor, test and assess as well as figure out the best order of operations and addressing your concerns

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The FDA has classified it as a Category 2 bulk drug substance, which restricts compounding pharmacies from producing it