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From 1,309 bioactive molecules screened, the computer analysis selected GHK at 1 micromolar and securinine at 18 micromolar as the optimal agents capable of reversing expression of 54 gene sets overexpressed in malignant invasive colon cancer

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NF-E2-Related factor 2 suppresses intestinal fibrosis by inhibiting reactive oxygen species-dependent TGF-1/SMADs pathway

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Marcano DC, Shin CS, Lee B, Isenhart LC, Liu X, Li F, Jester JV, Pflugfelder SC, Simpson J, Acharya G (2016) Synergistic cysteamine delivery nanowafer as an efficacious treatment modality for corneal cystinosis