Weight regain (around 6.0% of original body weight in the semaglutide group and 1.4% in the placebo group) occurred in the 28 weeks following treatment discontinuation, such that the mean change in body weight from baseline was 7.9% for semaglutide 2.4 mg and 1.3% for placebo, with an ongoing upward trend at the end of 80 weeks
It is not approved by the FDA, EMA, MHRA, PMDA, or any other regulatory authority for any therapeutic indication
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Compounding quality is not FDA-verified: Compounded products are not reviewed for potency, sterility or purity before dispensing, so provenance from a reputable 503A/503B pharmacy materially affects the safety profile [8]
"Qualified and trained health care professionals should be offering evidence-based interventions and treatments, and that can look like anything across the spectrum of nutrition counseling, intensive behavioral therapies, FDA-approved medications, or metabolic and bariatric surgery." A recent study found that just 0.44% of active-duty troops who qualify to take GLP-1 weight-loss medications, such as Wegovy, are prescribed them
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